Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk.
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چکیده
منابع مشابه
Pharmacokinetics in lactating women: prediction of alprazolam transfer into milk.
1. Alprazolam, a triazolobenzodiazepine, is extensively prescribed for the treatment of anxiety disorders, which predominantly affect women of child-bearing age. The purpose of the present study was to assess the pharmacokinetics of alprazolam and its two hydroxylated metabolites: 4-hydroxy-alprazolam and alpha-hydroxy-alprazolam in lactating human volunteers and to test the predictability of f...
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Five women undergoing acute Caesarean section were given an i.v. dose of 1600 mg tinidazole preoperatively as prophylaxis against anaerobic infection. Blood and breast milk samples were collected at 8 and 4 h intervals, respectively, for 120 h. Tinidazole concentrations were measured by means of high performance liquid chromatography (h.p.l.c). The concentration of tinidazole in breast milk was...
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Moxidectin, registered worldwide as a veterinary antiparasitic agent, is currently under development for humans for the treatment of onchocerciasis in collaboration with the World Health Organization. The objective of this study was to assess the pharmacokinetics of moxidectin in healthy lactating women, including the excretion into breast milk. Twelve women, ages 23 to 38 years, weighing 54 to...
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The objective of this study was to evaluate kinetics and the residual decline of tylosin in milk and plasma of lactating Najdi ewes following single intramuscular injection of tylosin at the dose of 10 mg/kg. Blood and milk samples were collected from the ewes before and at different time intervals after treatment. Tylosin concentrations were determined by microbiological agar plate assay using...
متن کاملLevonorgestrel pharmacokinetics in plasma and milk of lactating women who take 1.5 mg for emergency contraception.
BACKGROUND Progestin-only methods are among the contraceptive options available for breastfeeding women, however the doses of progestin used in emergency contraception (EC) have not been evaluated in nursing mothers. We therefore investigated the pharmacokinetics of 1.5 mg levonorgestrel (LNG) in lactating women. METHODS Twelve healthy exclusively breastfeeding volunteers received 1.5 mg LNG....
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1995
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.1995.tb05778.x